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Janardan P. Pandey, Emily Kistner-Griffin, Faisal F. Radwan, Navtej Kaur, Aryan M. Namboodiri, Laurel Black, Mary Ann Butler, Tania Carreón, Avima M. Ruder, Immunoglobulin Genes Influence the Magnitude of Humoral Immunity to Cytomegalovirus Glycoprotein B, The Journal of Infectious Diseases, Volume 210, Issue 11, 1 December 2014, Pages 1823–1826, https://doi.org/10.1093/infdis/jiu367
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Abstract
Human cytomegalovirus (HCMV) is a risk factor for many human diseases, but among exposed individuals, not everyone is equally likely to develop HCMV-spurred diseases, implying the presence of host genetic factors that might modulate immunity to this virus. Here, we show that antibody responsiveness to HCMV glycoprotein B (gB) is significantly associated with particular immunoglobulin GM (γ marker) genotypes. Anti-HCMV gB antibody levels were highest in GM 17/17 homozygotes, intermediate in GM 3/17 heterozygotes, and lowest in GM 3/3 homozygotes (28.2, 19.0, and 8.1 µg/mL, respectively; P = .014). These findings provide mechanistic insights in the etiopathogenesis of HCMV-spurred diseases.