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Eric G. Meissner, Dimitra Bon, Ludmila Prokunina-Olsson, Wei Tang, Henry Masur, Thomas R. O'Brien, Eva Herrmann, Shyamasundaran Kottilil, Anuoluwapo Osinusi, IFNL4-ΔG Genotype Is Associated With Slower Viral Clearance in Hepatitis C, Genotype-1 Patients Treated With Sofosbuvir and Ribavirin, The Journal of Infectious Diseases, Volume 209, Issue 11, 1 June 2014, Pages 1700–1704, https://doi.org/10.1093/infdis/jit827
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Abstract
Response to pegylated interferon-alpha and ribavirin (IFN-α/RBV) treatment for chronic hepatitis C virus (HCV) infection is influenced by host genetic factors, but their role for IFN-α–free, direct-acting antiviral (DAA) regimens is unclear. An exonic deletion allele (IFNL4-ΔG) bolsters the established association with IFN-α/RBV therapy treatment outcome of another IFNL4 variant, rs12979860, which is located upstream of IFNL3 (IL28B). We report that in patients treated with the DAA sofosbuvir along with RBV, IFNL4-ΔG is associated with slower early viral decay, due to slower loss of free virus (P = .039) and decreased drug efficacy (P = .048), suggesting functional relevance of IFN-λ4 in IFN-α–free DAA therapies.