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Jean-Christophe Meunier, Judith M. Gottwein, Michael Houghton, Rodney S. Russell, Suzanne U. Emerson, Jens Bukh, Robert H. Purcell, Vaccine-Induced Cross-Genotype Reactive Neutralizing Antibodies Against Hepatitis C Virus, The Journal of Infectious Diseases, Volume 204, Issue 8, 15 October 2011, Pages 1186–1190, https://doi.org/10.1093/infdis/jir511
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Abstract
We detected cross-reactive neutralizing antibodies (NtAb) against hepatitis C virus (HCV) in chimpanzees vaccinated with HCV-1 (genotype 1a) recombinant E1/E2 envelope glycoproteins. Five vaccinated chimpanzees, protected following HCV-1 challenge, were initially studied using the heterologous H77 (genotype 1a) HCVpp assay. All animals had developed NtAb after the second vaccination; 4 animals had reciprocal titers of ≥200 at the time of challenge. Using genotypes 1a–6a HCV pseudoparticles (HCVpp) and cell culture–derived HCV (HCVcc) assays, cross-reactive NtAb were detected against 1a, 4a, 5a, and 6a, with limited reactivity against 2a and 3a. Our study provides encouragement for the development of a recombinant envelope-based vaccine against hepatitis C.