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Catherine Yen, Jesùs Reyna Figueroa, Edgar Sánchez Uribe, Luz del Carmen-Hernández, Jacqueline E. Tate, Umesh D. Parashar, Manish M. Patel, Vesta Richardson López-Collado, Monovalent Rotavirus Vaccine Provides Protection Against an Emerging Fully Heterotypic G9P[4] Rotavirus Strain in Mexico, The Journal of Infectious Diseases, Volume 204, Issue 5, 1 September 2011, Pages 783–786, https://doi.org/10.1093/infdis/jir390
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Abstract
After the introduction of monovalent rotavirus vaccine (RV1) in Mexico in 2006–2007, diarrhea mortality and morbidity declined substantially among Mexican children under 5 years of age. In January 2010, surveillance identified the emergence of a novel G9P[4] rotavirus strain nationwide. We conducted a case-control study to assess the field effectiveness of RV1 against severe rotavirus gastroenteritis caused by this unusual strain and to determine whether the G9P[4] emergence was related to vaccine failure or failure to vaccinate. RV1 was 94% effective (95% confidence interval, 16%–100%) against G9P[4] rotavirus–related hospitalization, indicating that its emergence was likely unrelated to vaccine pressure.