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Rebecca N. Koehler, Anne M. Walsh, Elmar Saathoff, Sodsai Tovanabutra, Miguel A. Arroyo, Jeffrey R. Currier, Leonard Maboko, Michael Hoelsher, Merlin L. Robb, Nelson L. Michael, Francine E. McCutchan, Jerome H. Kim, Gustavo H. Kijak, Class I HLA-A*7401 Is Associated with Protection from HIV-1 Acquisition and Disease Progression in Mbeya, Tanzania, The Journal of Infectious Diseases, Volume 202, Issue 10, 15 November 2010, Pages 1562–1566, https://doi.org/10.1086/656913
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Abstract
Here we explore associations between HLA variation and human immunodeficiency virus type 1 (HIV-1) acquisition and disease progression in a community cohort in Mbeya, Tanzania, a region that, despite harboring high rates of HIV- 1 infection, remains understudied. African-specific allele HLA-A*74:01 was associated with decreased risk of infection (odds ratio [OR], 0.37; 95% confidence interval [CI], 0.14–0.80; P = .011) and with protection from CD4+ cell counts <200 cells/uL in women (OR, 0.31; 95% CI, 0.07–0.91; P = .032) and men (OR, 0.15; 95%CI, 0.01–0.78; P = .020). These associations remained significant after adjustment for linkage disequilibrium with HLA-B and HLA-C alleles. This observation calls for additional investigation of mechanisms by which HLA-A*74:01 may influence HIV-1 acquisition and control of the infection.