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Catherine A. Blish, Laura Sangaré, Bradley R. Herrin, Barbra A. Richardson, Grace John-Stewart, Judd L. Walson, Changes in Plasma Cytokines after Treatment of Ascaris lumbricoides Infection in Individuals with HIV-1 Infection, The Journal of Infectious Diseases, Volume 201, Issue 12, 15 June 2010, Pages 1816–1821, https://doi.org/10.1086/652784
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Abstract
Albendazole treatment of individuals with human immunodeficiency virus type 1 (HIV-1) and Ascaris lumbricoides coinfection has led to significantly improved CD4+ cell counts and a trend for lower plasma HIV-1 RNA levels in a previous randomized placebo-controlled trial. To define mechanisms by which deworming contributed to changes in markers of HIV- 1 disease progression, plasma cytokine levels were evaluated. Albendazole treatment, compared with placebo, was associated with significantly decreased plasma interleukin (IL) 10 levels (P=.04) but was not associated with significant changes in levels of IL-1b, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-12p70, IL- 13, interferon γ, tumor necrosis factor α, or thymic stromal lymphopoietin. Treatment of A. lumbricoides co-infectionmay delay HIV-1 disease progression by reducing helminth-induced, IL-10-mediated immunosuppression.
- cytokine
- hiv
- tumor necrosis factors
- interleukin-1
- albendazole
- aldesleukin
- ascariasis
- ascaris lumbricoides
- cell count
- disease progression
- hiv-1
- interferons
- interleukin-4
- interleukin-5
- interleukin-7
- interleukin-8
- interleukins
- plasma
- natural immunosuppression
- aftercare
- helminths
- interleukin-6
- rna
- human leukocyte interferon
- coinfection
- hiv-1 infection
- thymic stromal lymphopoietin