-
Views
-
Cite
Cite
Honglin Chen, Xi Wen, Kelvin K. W. To, Pui Wang, Herman Tse, Jasper F. W. Chan, Hoi-Wah Tsoi, Kitty S. C. Fung, Cindy W. S. Tse, Rodney A. Lee, Kwok-Hung Chan, Kwok-Yung Yuen, Quasispecies of the D225G Substitution in the Hemagglutinin of Pandemic Influenza A(H1N1) 2009 Virus from Patients with Severe Disease in Hong Kong, China, The Journal of Infectious Diseases, Volume 201, Issue 10, 15 May 2010, Pages 1517–1521, https://doi.org/10.1086/652661
- Share Icon Share
Abstract
The D225G (aspartic acid to glycine) substitution in the hemagglutinin of H1N1 influenza virus may alter its receptorbinding specificity. Direct analysis of polymorphisms in 126 amino acids spanning the receptor-binding site in the hemagglutinin of pandemic H1N1 2009 virus from 117 clinical specimens in Hong Kong found the D225G substitution for 7 (12.5%) of 57 patients with severe disease and for 0 (0%) of 60 patients with mild disease. D225G quasispecies were identified mainly in endotracheal aspirate samples and were identified less frequently in nasopharyngeal aspirate samples from patients with severe disease. Continuous monitoring of the prevalence and tissue tropism of this variant during its circulation among humans is important.