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Martin P. Grobusch, Julian J. Gabor, John J. Aponte, Norbert G. Schwarz, Marc Poetschke, Jenny Doernemann, Katharina Schuster, Kai B. Koester, Katharina Profanter, Lea B. Borchert, Florian Kurth, Peter Pongratz, Saadou Issifou, Bertrand Lell, Peter G. Kremsner, No Rebound of Morbidity Following Intermittent Preventive Sulfadoxine-Pyrimethamine Treatment of Malaria in Infants in Gabon, The Journal of Infectious Diseases, Volume 200, Issue 11, 1 December 2009, Pages 1658–1661, https://doi.org/10.1086/647990
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Abstract
In the context of a trial studying intermittent preventive sulfadoxine-pyrimethamine treatment of malaria in infants in Lambaréné, Gabon, children aged 18–30 months were followed up after having received their last dose at an age of 15 months. In the intention-to-treat population, the protective efficacy against all malaria episodes was −18.0 (95% confidence interval, −97.4 to 29.5; P=.529). The protective efficacy against first or only anemia episode was −45.3 (95% confidence interval, −234.5 to 36.3; P=.375). The protective efficacies were negative and were not statistically significant. These results do not appear to support the concept of a rebound effect after intermittent preventive sulfadoxine-pyrimethamine treatment of malaria in infants
Clinical trials registrationNCT00167843