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Marianne C. Jacobsen, Rodolphe Thiébaut, Christopher Fisher, Delali Sefe, Margaret Clapson, Nigel Klein, Helen E. Baxendale, Pediatric Human Immunodeficiency Virus Infection and Circulating IgD+ Memory B Cells, The Journal of Infectious Diseases, Volume 198, Issue 4, 15 August 2008, Pages 481–485, https://doi.org/10.1086/590215
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Abstract
Levels of circulating naive and memory B cells were measured in human immunodeficiency virus (HIV)-infected children and control subjects to determine whether the irreversible depletion of memory B cells described in HIV-infected adults occurs in children with HIV infection. Depletion of circulating IgD+ memory B cells was seen in HIV-infected children despite control of the HIV load with highly active antiretroviral therapy (HAART) (P=.04). IgD+ memory B cell percentages did not correlate with CD4+ cell percentages (P=.27) or disease duration (P=.26). Naive/transitional and IgD− memory B cell numbers were not affected. Pediatric HIV infection is associated with selective depletion of circulating IgD+ memory B cells despite control of the HIV load with HAART.