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Sarah Williams-Blangero, John L. VandeBerg, Janardan Subedi, Bharat Jha, Rodrigo Corrêa-Oliveira, John Blangero, Localization of Multiple Quantitative Trait Loci Influencing Susceptibility to Infection with Ascaris lumbricoides, The Journal of Infectious Diseases, Volume 197, Issue 1, 1 January 2008, Pages 66–71, https://doi.org/10.1086/524060
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Abstract
A linkage-based genome scan of 1258 members of a single pedigree of the Jirel population of Nepal localized 6 potential quantitative trait loci (QTLs) influencing susceptibility to infection with Ascaris lumbricoides Ascaris lumbricoides, the most common soil-transmitted intestinal helminth. Three QTLs exhibited genomewide significance, including QTLs on chromosomes 13 (logarithm of the odds ratio [LOD] score, 3.37; genomewide P = .013), 8 (LOD score, 3.03; genomewide P = .031), and 11 (LOD score, 3.19; genomewide P = .020). Another QTL on chromosome 1 approached significance (LOD score, 2.72; genomewide P = .067). There was suggestive evidence of linkage for 2 additional loci on chromosomes 1 and 13.