Extract

This supplement to the Journal of Infectious Diseases is dedicated to the memories of Jim Orzechowski (1944–2003) and Michael Kiley (1942–2004), individuals who were instrumental in bringing biosafety level 4 (BSL4) biocontainment into the 21st century.

Jim Orzechowski, a Canadian from the prairies of Manitoba, received a degree in architecture fromNorth Dakota State University in 1970, joined the architectural firm of Smith Carter, and, within 4 years, was a partner in the company. Beginning in 1978, Smith Carter began designing medical structures, and, in 1987, Jim led a consortium that won the bid to build new laboratories for Canada's health and agriculture ministries. Patient and always careful, the team took more than 5 years to design what has become the prototype for modern BSL4 laboratories. The Canadian Science Centre for Human and Animal Health (CSCHAH) was dedicated in 1999 and has already contributed major new knowledge to high-containment biomedical science. Jim's company now designs BSL4 laboratories in the United States and beyond.

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