-
Views
-
Cite
Cite
Anthony Jaworowski, Deborah D. Kamwendo, Philip Ellery, Secondo Sonza, Victor Mwapasa, Eyob Tadesse, Malcolm E. Molyneux, Stephen J. Rogerson, Steven R. Meshnick, Suzanne M. Crowe, CD16+ Monocyte Subset Preferentially Harbors HIV-1 and Is Expanded in Pregnant Malawian Women with Plasmodium falciparum Malaria and HIV-1 Infection, The Journal of Infectious Diseases, Volume 196, Issue 1, 1 July 2007, Pages 38–42, https://doi.org/10.1086/518443
- Share Icon Share
Abstract
In a cross-sectional study, monocyte subsets in placental, cord, and maternal peripheral blood from pregnant Malawian women with human immunodeficiency virus (HIV)-1 infection and/or malaria were analyzed. HIV-uninfected Malawian women had higher baseline proportions of CD16+ monocytes than those reported for healthy adults in developed countries. Malaria was associated with an increase in the proportion of CD16+ monocytes that was significant in women coinfected with HIV-1. CD16+ monocytes expressed higher CCR5 levels than did CD14hi/CD16− monocytes and were significantly more likely to harbor HIV-1. These data suggest a role for CD16+ monocytes in the pathogenesis of maternal malaria and HIV-1 infections.