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Christina M. Marra, April P. Colina, Charmie Godornes, Lauren C. Tantalo, Maritza Puray, Arturo Centurion‐Lara, Sheila A. Lukehart, Antibiotic Selection May Contribute to Increases in Macrolide‐Resistant Treponema pallidum, The Journal of Infectious Diseases, Volume 194, Issue 12, 15 December 2006, Pages 1771–1773, https://doi.org/10.1086/509512
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Abstract
To determine whether the 23S rRNA mutation that confers macrolide resistance is present in >1 Treponema pallidum strain, 58 isolates collected between 2001 and 2005 were screened for this mutation and for an unrelated sequence that distinguishes between strains. The odds of identifying a macrolide‐resistant strain increased over time (P=.006). In subjects who had received macrolides in the previous year, the relative risk of harboring a resistant strain was 2.2 (95% confidence interval, 1.1–4.4; P=.02). The macrolide‐resistant strains were not identical. These findings suggest that macrolide resistance may be increasing in multiple strains in response to antibiotic pressure.