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Todd Hulgan, Stephen Raffanti, Asghar Kheshti, Robert B. Blackwell, Peter F. Rebeiro, Gema Barkanic, Brandon Ritz, Timothy R. Sterling, CD4 Lymphocyte Percentage Predicts Disease Progression in HIV-Infected Patients Initiating Highly Active Antiretroviral Therapy with CD4 Lymphocyte Counts >350 Lymphocytes/mm3, The Journal of Infectious Diseases, Volume 192, Issue 6, 15 September 2005, Pages 950–957, https://doi.org/10.1086/432955
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Abstract
BackgroundThe optimal timing of highly active antiretroviral therapy (HAART) in human immunodeficiency virus (HIV)–infected patients with ⩾200 absolute CD4 lymphocytes/mm3 is unknown. CD4 lymphocyte percentage could add prognostic information
MethodsPersons who initiated HAART between 1 January 1998 and 1 January 2003, received ⩾30 days of therapy, and had baseline CD4 lymphocyte data available were included in the study. The log-rank test for time to event and Cox proportional hazards models were used to determine predictors of a new acquired immunodeficiency syndrome–defining illness or death
ResultsA total of 788 patients met the inclusion criteria. At baseline, subjects had a median of 225 CD4 lymphocytes/mm3 and 17% CD4 lymphocytes. Subjects with <17% CD4 lymphocytes had earlier disease progression, compared with subjects with ⩾17%, both in the entire cohort (P<.0001) and of those subjects with >350 absolute CD4 lymphocytes/mm3 at baseline (P=.03). CD4 lymphocyte percentage <17% was the strongest predictor of disease progression among subjects in this latter group (hazard ratio, 3.57; P=.045)
ConclusionsIn this cohort, CD4 lymphocyte percentage predicted disease progression in HIV-infected subjects who initiated therapy with >350 CD4 lymphocytes/mm3. This information may help identify persons who will derive the greatest benefit from initiation of HAART