-
Views
-
Cite
Cite
Craig R. Cohen, Kasra M. Koochesfahani, Amalia S. Meier, Caixia Shen, Karuna Karunakaran, Beartrice Ondondo, Teresa Kinyari, Nelly R. Mugo, Rosemary Nguti, Robert C. Brunham, Immunoepidemiologic Profile of Chlamydia trachomatis Infection: Importance of Heat-Shock Protein 60 and Interferon-γ, The Journal of Infectious Diseases, Volume 192, Issue 4, 15 August 2005, Pages 591–599, https://doi.org/10.1086/432070
- Share Icon Share
Abstract
Epidemiological, animal, and in vitro investigations suggest that Chlamydia trachomatis infection engenders acquired immunity, the basis for which is incompletely defined, especially in humans. In a prospective cohort study of women at high risk for C. trachomatis infection, we found that, at baseline and after adjustment for age and other potential confounding variables, production of interferon-γ by peripheral-blood mononuclear cells (PBMCs) stimulated with chlamydia heat-shock protein 60 strongly correlated with protection against incident C. trachomatis infection. This investigation supports a direct role for C. trachomatis–specific immune responses in altering the risk of infection and suggests immune correlates of protection that are potentially useful in vaccine development