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Chenqi Zhao, Réjean Cantin, Marie Breton, Barbara Papadopoulou, Michel J. Tremblay, DC-SIGN-Mediated Transfer of HIV-1 Is Compromised by the Ability of Leishmania infantum to Exploit DC-SIGN as a Ligand, The Journal of Infectious Diseases, Volume 191, Issue 10, 15 May 2005, Pages 1665–1669, https://doi.org/10.1086/429673
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Abstract
DC-SIGN (dendritic cell—specific intercellular adhesion molecule 3—grabbing nonintegrin) binds human immunodeficiency virus type 1 (HIV-1) and facilitates transfer of virus to permissive cells. Leishmania parasites also exploit DC-SIGN as a receptor. Here, we report that transfer of HIV-1 to target cells is markedly reduced when DC-SIGN+ cells are preincubated with Leishmania amastigotes before pulsing with virions. Moreover, binding of HIV-1 to DC-SIGNM+ cells is diminished by the presence of Leishmania amastigotes. Our findings provide novel insight into the complex interactions between HIV-1 and Leishmania parasites. The ability of both HIV-1 and Leishmania parasites to bind to the same cell-surface constituent to gain entry into dendritic cells might have an impact on the immunological and pathological events associated with HIV-1 infection.