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Sarah Joseph, Frances M. Jones, Maureen E. Laidlaw, Gamal Mohamed, Patrice A. Mawa, Proscovia B. Namujju, Kizza Kizza, Watera Watera, James A. G. Whitworth, David W. Dunne, Alison M. Elliott, Impairment of the Schistosoma mansoni-Specific Immune Responses Elicited by Treatment with Praziquantel in Ugandans with HIV-1 Coinfection, The Journal of Infectious Diseases, Volume 190, Issue 3, 1 August 2004, Pages 613–618, https://doi.org/10.1086/422396
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Abstract
We show that Ugandan adults coinfected with Schistosoma mansoni and human immunodeficiency virus type 1 (HIV-1) are able to mount S. mansoni-specific immune responses but that few such responses increase after treatment with praziquantel (PZQ). Levels of soluble wormantigen (SWA)-specific immunoglobulin (Ig) G1, IgG2, IgG3, IgG4, interleukin (IL)- 4, and IL-5 increased significantly in HIV-negative participants after treatment with PZQ, whereas most soluble egg antigen- specific antibody responses and levels of interferon-γ were unaltered. Only levels of SWA-specific IL-5 increased in HIV- 1-coinfected participants after treatment. These deficiencies in immune responses may account for the previously reported increased susceptibility to infection and reinfection with S. mansoni in individuals coinfected with HIV-1.