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Edward Walsh, Ann R. Falsey, Humoral and Mucosal Immunity in Protection from Natural Respiratory Syncytial Virus Infection in Adults, The Journal of Infectious Diseases, Volume 190, Issue 2, 15 July 2004, Pages 373–378, https://doi.org/10.1086/421524
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Abstract
Virus-specific nasal immunoglobulin (Ig) A and serum antibody titers in 67 respiratory syncytial virus (RSV)-infected adults were compared with titers in age-matched uninfected control subjects. Control subjects had significantly higher levels of nasal IgA and serum IgG to the RSV F, Ga, and Gb proteins than infected subjects. Serum neutralizing-antibody titers to group A and B RSV strains were also lower in infected subjects, although differences were not as large. Multivariate analysis found that low RSV-specific nasal IgA was an independently significant risk factor for RSV infection.