-
Views
-
Cite
Cite
Richard L. Ward, David I. Bernstein, Vicki E. Smith, Donna S. Sander, Alan Shaw, Joseph J. Eiden, Penny Heaton, Paul A. Offit, H. Fred Clark, Rotavirus Immunoglobulin A Responses Stimulated by Each of 3 Doses of a Quadrivalent Human/ Bovine Reassortant Rotavirus Vaccine, The Journal of Infectious Diseases, Volume 189, Issue 12, 15 June 2004, Pages 2290–2293, https://doi.org/10.1086/421248
- Share Icon Share
Abstract
A quadrivalent precursor to the pentavalent rotavirus vaccine candidate RotaTeq was evaluated in a 3-dose, 439-subject study. To determine immunogenicity, the quantity of rotavirus immunoglobulin A (IgA) in stool specimens obtained, at 1 of 10 study sites, from 37 placebo and 37 vaccine recipients was measured. None of the placebo recipients showed a clinically important (⩾3-fold) increase in stool rotavirus IgA, whereas 31 vaccine recipients showed an increase after at least 1 dose of vaccine. In total, 16, 19, and 15 vaccine recipients had increases after 1, 2, and 3 doses, respectively, indicating that a 3-dose regimen increased the immune response elicited by this vaccine.