-
Views
-
Cite
Cite
Terri Moore, Charles O. Ekworomadu, Francis O. Eko, LuCinda MacMillan, Kiantra Ramey, Godwin A. Ananaba, John W. Patrickson, Periakaruppan R. Nagappan, Deborah Lyn, Carolyn M. Black, Joseph U. Igietseme, Fc Receptor–Mediated Antibody Regulation of T Cell Immunity against Intracellular Pathogens, The Journal of Infectious Diseases, Volume 188, Issue 4, 15 August 2003, Pages 617–624, https://doi.org/10.1086/377134
- Share Icon Share
Abstract
Immunity to intracellular microbial pathogens, including Chlamydia species, is controlled primarily by cell-mediated effector mechanisms, yet, the absence of antibodies results in inefficient microbial clearance. We investigated the hypothesis that certain Fc receptor functions promote the rapid induction of elevated T helper type 1 (Th1) response, which effectively clears chlamydiae. FcR−/− mice exhibited a delayed and reduced frequency of Chlamydia-specific Th1 cells, compared to FcR+/+ mice. In vitro, antichlamydial antibodies increased the rate of Th1 activation by FcR+/+ but not FcR−/− antigen-presenting cells. FcR−/− dendritic cells and the T cell–associated IgG2A and IgA mediate enhanced Th1 activation by antibodies. Immunization with chlamydia-antibody complexes induced elevated and protective Th1 response. These results provide a mechanistic basis for requiring both T cell and humoral immune responses in protective immunity and vaccine evaluation. Findings offer a paradigm in host defense wherein different effector components function indirectly to maximize the principal effector mechanism