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Leland J Yee, Kevin A Perez, Jianming Tang, Dirk J. van Leeuwen, Richard A Kaslow, Association of CTLA4 Polymorphisms with Sustained Response to Interferon and Ribavirin Therapy for Chronic Hepatitis C Virus Infection, The Journal of Infectious Diseases, Volume 187, Issue 8, 15 April 2003, Pages 1264–1271, https://doi.org/10.1086/374561
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Abstract
Cytotoxic T lymphocyte antigen-4 (CTLA4) suppresses cytotoxic T lymphocyte activity. We examined the associations of CTLA4 single-nucleotide polymorphisms (SNPs) at promoter site −318 and exon-1 site 49 with clearance of hepatitis C virus (HCV) after treatment with combination interferon-α plus ribavirin (IFN-α+R) therapy in 79 white sustained responders (SRs) and 79 nonresponders (NRs). SRs had higher frequencies of 49G, alone (odds ratio [OR], 2.3; P=.042) and tightly linked with −318C in a haplotype (OR, 2.4; P=.030). Homozygosity for the −318C-49G haplotype was even more frequent among SRs (OR, 5.2; P=.049). Comparably strong associations persisted after multivariable analysis. Relationships were not seen with non-1 genotype viruses (OR, 0.93–1.25; P>.25). Virus load also declined more rapidly in carriers of both 49G (P=.0095) and the −318C-49G haplotype. CTLA4 49G in exon 1 alone and in a haplotype with −318C promoter is associated with sustained IFNα+R response in white patients with HCV genotype 1 infection
- polymorphism
- hepatitis c, chronic
- drug clearance
- antigens
- exons
- genotype
- haplotypes
- homozygote
- interferons
- single nucleotide polymorphism
- ribavirin
- t-lymphocytes, cytotoxic
- viral load result
- infections
- viruses
- russell-silver syndrome
- human leukocyte interferon
- hepatitis c virus
- somatostatin receptor scintigraphy
- hepatitis c virus genotype 1