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Xiao-Li Huang, Zheng Fan, Lian Zheng, Luann Borowski, Hongyi Li, Elaine K. Thomas, William H. Hildebrand, Xiao-Qing Zhao, Charles R. Rinaldo, Priming of Human Immunodeficiency Virus Type 1 (HIV-1)–Specific CD8+ T Cell Responses by Dendritic Cells Loaded with HIV-1 Proteins, The Journal of Infectious Diseases, Volume 187, Issue 2, 15 January 2003, Pages 315–319, https://doi.org/10.1086/346054
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Abstract
Proteins may serve as ideal CD8+ T cell immunogens for human immunodeficiency virus type 1 (HIV-1) if they can be delivered to and processed through the human leukocyte antigen class I pathway. This study shows that human blood monocyte–derived dendritic cells loaded with liposome-complexed HIV-1 proteins and matured with CD40 ligand can prime CD8+ T cells to HIV-1 in vitro. Whole HIV-1 protein in liposome may be an effective immunogen for HIV-1 vaccine protocols