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John E. McGowan, Holly A. Hill, Nataliya V. Volkova, Rachel M. Lawton, Michael J. Haber, Fred C. Tenover, the Project ICARE (Intensive Care Antimicrobial Resistance Epidemiology) Hospitals, Does Antimicrobial Resistance Cluster in Individual Hospitals?, The Journal of Infectious Diseases, Volume 186, Issue 9, 1 November 2002, Pages 1362–1365, https://doi.org/10.1086/344323
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Abstract
Factors that affect the resistance rates for an organism-drug combination in a given hospital also might influence resistance rates for other organism-drug combinations. We examined correlations between resistance prevalence in non–intensive care inpatient areas of 41 hospitals participating in phase 3 (1998–1999) of Project ICARE (Intensive Care Antimicrobial Resistance Epidemiology). We focused on statistically significant (P<.05) Pearson correlation coefficients for methicillin-resistant Staphylococcus aureus coagulase-negative staphylococci, vancomycin-resistant enterococci, and resistance to third-generation cephalosporins, imipenem, and fluoroquinolones in Escherichia coli, Klebsiella pneumoniae, Enterobacter species, and Pseudomonas aeruginosa. Resistance prevalence rates in individual hospitals were not strongly correlated among gram-positive organisms, and few correlations were seen between rates in gram-positive and gram-negative organisms. More frequent significant associations were found among resistance rates for gram-negative organisms. Resistance to third-generation cephalosporins in K. pneumoniae was significantly correlated with the majority of other sentinel antimicrobial-resistant organisms. High prevalence of this organism may serve as a marker for more generalized resistance problems in hospital inpatient areas
- pseudomonas aeruginosa
- cephalosporins
- epidemiology
- drug resistance, microbial
- enterobacter
- fluoroquinolones
- gram-positive cocci
- imipenem
- inpatients
- intensive care
- klebsiella pneumoniae
- staphylococcus, coagulase negative
- antimicrobials
- escherichia coli
- methicillin-resistant staphylococcus aureus
- vancomycin-resistant enterococcus