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Kerrie Tosh, Sarah Meisner, M. Ruby Siddiqui, Karuppiah Balakrishnan, Satish Ghei, Marina Golding, Utpal Sengupta, Ramasamy M. Pitchappan, Adrian V. S. Hill, A Region of Chromosome 20 Is Linked to Leprosy Susceptibility in a South Indian Population, The Journal of Infectious Diseases, Volume 186, Issue 8, 15 October 2002, Pages 1190–1193, https://doi.org/10.1086/343806
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Abstract
A major susceptibility locus for leprosy has recently been mapped on chromosome 10 (10p13) by genome-wide linkage analysis. Microsatellite markers from this genome screen that showed suggestive evidence of linkage to leprosy were evaluated in an additional 140 families with affected sib pairs. A second region of linkage has thus been identified on chromosome 20 (20p12). The peak of linkage lies at marker D20S115 which has a significant single-point maximum logarithm of odds score of 3.48 (P=.00003). Transmission disequilibrium testing of the microsatellite markers in 20p12 showed that the marker D20S835 is associated with protection against leprosy (P=.021), which suggests that a locus controlling susceptibility lies close to this marker