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Xiyan Xu, Catherine B. Smith, Bruce A. Mungall, Stephen E. Lindstrom, Henrietta E. Hall, Kanta Subbarao, Nancy J. Cox, Alexander Klimov, Intercontinental Circulation of Human Influenza A(H1N2) Reassortant Viruses during the 2001–2002 Influenza Season, The Journal of Infectious Diseases, Volume 186, Issue 10, 15 November 2002, Pages 1490–1493, https://doi.org/10.1086/344738
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Abstract
Reassortant influenza A viruses bearing the H1 subtype of hemagglutinin (HA) and the N2 subtype of neuraminidase (NA) were isolated from humans in the United States, Canada, Singapore, Malaysia, India, Oman, Egypt, and several countries in Europe during the 2001–2002 influenza season. The HAs of these H1N2 viruses were similar to that of the A/New Caledonia/20/99(H1N1) vaccine strain both antigenically and genetically, and the NAs were antigenically and genetically related to those of recent human H3N2 reference strains, such as A/Moscow/10/99(H3N2). All 6 internal genes of the H1N2 reassortants examined originated from an H3N2 virus. This article documents the first widespread circulation of H1N2 reassortants on 4 continents. The current influenza vaccine is expected to provide good protection against H1N2 viruses, because it contains the A/New Caledonia/20/99(H1N1) and A/Moscow/10/99(H3N2)-like viruses, which have H1 and N2 antigens that are similar to those of recent H1N2 viruses
- influenza
- antigens
- canada
- egypt
- genes
- hemagglutinins
- india
- influenza a virus
- influenza vaccines
- malaysia
- moscow
- neonatal abstinence syndrome
- neuraminidase
- new caledonia
- oman
- reassortant viruses
- singapore
- vaccines
- viruses
- influenza a virus, h1n1 subtype
- influenza a virus, h3n2 subtype
- swine influenza
- swine-origin influenza virus