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Francesco Dieli, Marita Troye-Blomberg, Juraj Ivanyi, Jean Jacques Fournié, Alan M. Krensky, Marc Bonneville, Marie Alix Peyrat, Nadia Caccamo, Guido Sireci, Alfredo Salerno, Granulysin-Dependent Killing of Intracellular and Extracellular Mycobacterium tuberculosis by Vγ9/Vδ2 T Lymphocytes, The Journal of Infectious Diseases, Volume 184, Issue 8, 15 October 2001, Pages 1082–1085, https://doi.org/10.1086/323600
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Abstract
Contribution of Vγ9/Vδ2 T lymphocytes to immune protection against Mycobacterium tuberculosis is still a matter of debate. It was reported earlier that Vγ9/Vδ2 T lymphocytes kill macrophages harboring live M. tuberculosis through a granule-dependent mechanism that results in killing of intracellular bacilli. This study found that Vγ9/Vδ2 T lymphocytes reduce the viability of both extracellular and intracellular M. tuberculosis. Granulysin and perforin, both detected in Vγ9/Vδ2 T lymphocytes, play a major role, which indicates that Vγ9/Vδ2 T lymphocytes directly contribute to a protective host response against M. tuberculosis infection