-
Views
-
Cite
Cite
Elio Cenci, Antonella Mencacci, Andrea Casagrande, Paolo Mosci, Francesco Bistoni, Luigina Romani, Impaired Antifungal Effector Activity but Not Inflammatory Cell Recruitment in Interleukin-6-Deficient Mice with Invasive Pulmonary Aspergillosis, The Journal of Infectious Diseases, Volume 184, Issue 5, 1 September 2001, Pages 610–617, https://doi.org/10.1086/322793
- Share Icon Share
Abstract
A murine model of infection, in which immunocompetent or immunosuppressed interleukin-6–deficient (IL-6−/−) mice were infected intranasally with Aspergillus fumigatus conidia and were monitored for parameters of fungal colonization and innate and adaptive immunity, was used to assess the role of IL-6 in invasive pulmonary aspergillosis (IPA). The results indicate that IL-6−/− mice were more susceptible than wild-type mice to IPA. Susceptibility was associated with increased inflammatory pathology, decreased antifungal effector functions of phagocytes, and impaired development of protective type 1 responses. Exposure to exogenous IL-6 restored antifungal effector activity