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Caroline A. Sabin, Alessandro Cozzi Lepri, Helen Devereux, Andrew N. Phillips, Clive Loveday, Christine A. Lee, Relationships among the Detection of p24 Antigen, Human Immunodeficiency Virus (HIV) RNA Level, CD4 Cell Count, and Disease Progression in HIV-Infected Individuals with Hemophilia, The Journal of Infectious Diseases, Volume 184, Issue 4, 15 August 2001, Pages 511–514, https://doi.org/10.1086/322045
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Abstract
The aim of this study was to assess the relationships among the detection of p24 antigen, human immunodeficiency virus (HIV) RNA level, CD4 cell count, and disease progression in 111 males with hemophilia who were infected with HIV for ⩽20 years. Sixty-four individuals (58%) developed p24 antigenemia a median of 11.6 years after seroconversion. The time to first detection of p24 antigen was shorter among those who were older (P=.04) and those with a high initial HIV RNA level (P=.006). The median HIV RNA level and CD4 cell count at the time of the detection of p24 antigen were 4.95 log10 copies/mL and 100 cells/mm3, respectively. In univariate analyses, p24 antigenemia was associated with more-rapid progression to AIDS (relative hazard [RH], 5.50; P=.0001). The effect was reduced (RH, 1.85; P=.06) after adjusting for CD4 cell counts and HIV RNA levels during follow-up, age, and calendar year. A significant relationship between p24 antigenemia and death was nonsignificant after adjusting for CD4 cell count