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Szu-Min Hsieh, Sung-Ching Pan, Chien-Ching Hung, Hsing-Chun Tsai, Mao-Yuan Chen, Shan-Chwen Chang, Association between Cytomegalovirus-Specific Reactivity of T cell Subsets and Development of Cytomegalovirus Retinitis in Patients with Acquired Immunodeficiency Syndrome , The Journal of Infectious Diseases, Volume 184, Issue 11, 1 December 2001, Pages 1386–1391, https://doi.org/10.1086/324419
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Abstract
The association between cytomegalovirus (CMV)–specific reactivity of T cell subsets and development of CMV retinitis (CMV-R) was prospectively studied in 50 CMV-seropositive AIDS patients. The frequency of CMV-specific CD69 expression on CD8 T cells was similar in patients with and patients without CMV-R (median, 1.0% vs. 1.2%; P=.14). However, the frequency of CMV-specific CD69 expression on CD4 T cells was significantly lower in patients with CMV-R than in those without CMV-R (median, 0.4% vs. 2.25%; P<.001). CMV-specific CD4 T cell reactivity in patients who developed CMV-R shortly after starting highly active antiretroviral therapy (HAART) remained low, although the CD4 cell counts increased markedly. Therefore, development of CMV-R is associated with a poor CMV-specific reactivity of CD4 T cells but not with poor reactivity of CD8 T cells. Development of CMV-R after initiation of HAART is associated with a poor reconstitution of CMV-specific immune response, rather than with immune rebound