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Yolanda Barber, Carmen Rubio, Elvira Fernández, Manuel Rubio, Joan Fibla, Host Genetic Background at CCR5 Chemokine Receptor and Vitamin D Receptor Loci and Human Immunodeficiency Virus (HIV) Type 1 Disease Progression among HIV-Seropositive Injection Drug Users, The Journal of Infectious Diseases, Volume 184, Issue 10, 15 November 2001, Pages 1279–1288, https://doi.org/10.1086/324000
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Abstract
The effect of polymorphisms on genes encoding the CCR5 chemokine receptor and vitamin D receptor (VDR) in human immunodeficiency virus (HIV) type 1 disease progression was analyzed in a cohort of 185 HIV-seropositive injection drug users. Results confirmed a lack of association in patients with HIV disease between CCR5 wtΔ32 heterozygosity and a slow progression to AIDS and to a CD4 cell count <200 cells/μL. In contrast, a more rapid disease progression was associated with the VDR-BB genotype. A higher proportion of this genotype was found in patients with <200 CD4 cells/μL (P=.009; odds ratio [OR], 2.4; 95% confidence interval [CI], 1.3–4.7), as well as a faster progression both to AIDS (1993 CDC classification [CDC 1993]) and to a CD4 cell count <200 cells/μL. When the analysis was restricted to patients with a VDR-bb genetic background, patients with CCR5 wtΔ32 heterozygosity were overrepresented in CDC 1993 nonprogressors (P=.033; OR, 0.28; 95% CI, 0.08–0.92) and in those with >200 CD4 cells/μL (P=.062; OR, 0.26; 95% CI, 0.06–1.08). Also, patients with CCR5 wtΔ32 heterozygosity showed a slow progression both to AIDS CDC 1993 and to a CD4 cell count <200 cells/μL
- hiv
- acquired immunodeficiency syndrome
- polymorphism
- cd4 count determination procedure
- cd4 positive t-lymphocytes
- centers for disease control and prevention (u.s.)
- disease progression
- genes
- genotype
- heterozygote
- hiv seropositivity
- hiv-1
- homozygote
- vitamin d3 receptor
- chemokine (c-c motif) receptor 5
- chemokine receptors
- intravenous drug users
- anti-retroviral agents
- host (organism)
- genetic background