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Bertrand Visse, Bruno Dumont, Jean-Marie Huraux, Anne-Marie Fillet, Single Amino Acid Change in DNA Polymerase Is Associated with Foscarnet Resistance in a Varicella-Zoster Virus Strain Recovered from a Patient with AIDS, The Journal of Infectious Diseases, Volume 178, Issue Supplement_1, November 1998, Pages S55–S57, https://doi.org/10.1086/514257
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Abstract
The genetic characterization of a foscarnet-resistant strain of varicella-zoster virus (VZV) that was isolated from a patient with AIDS is reported. Compared with the sequence of the Dumas reference strain, this strain, which was isolated from a patient in whom foscarnet treatment failed, had two point mutations. The emergence of one of the mutations, which includes a change from a glutamic acid to a lysine at position 512 in the DNA polymerase, suggests that this mutation is implicated in the VZV foscarnet resistance. The other mutation, which replaces serine 863 by a glycine, is also present in 2 susceptible strains—Oka and a wild-type isolate.