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Alain Strady, Jean Lang, Michel Lienard, Christine Blondeau, Roland Jaussaud, Stanley A. Plotkin, Antibody Persistence Following Preexposure Regimens of Cell-Culture Rabies Vaccines: 10-Year Follow-Up and Proposal for a New Booster Policy, The Journal of Infectious Diseases, Volume 177, Issue 5, May 1998, Pages 1290–1295, https://doi.org/10.1086/515267
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Abstract
Subjects (n = 312) received either the human diploid cell rabies vaccine (HDCV) or the purified Vero cell rabies vaccine (PVRV) according to either two-injection (days 0 and 28) or three-injection (days 0, 7, and 28) primary regimens. They received a booster injection at 1 year. Rabies antibody levels were measured after the primary series and the booster and then each year for the next 10 years. The results confirm the superior long-term immunogenicity of the three-injection over the two-injection protocol. HDCV and PVRV in three doses were equally immunogenic. A booster injection at 1 year provides long-term seroconversion (titer ⩾0.5 IU/mL). Antibody titers 2 weeks after the 1-year booster allowed prediction of long-term immunity. Good responders, with titers ⩾30 IU/mL, were protected for at least 10 years. An algorithm for differentiation between good responders and poor responders with respect to vaccine booster strategies is proposed.