-
Views
-
Cite
Cite
Bart Jan Kullberg, Mihai G. Netea, Jo H. A. J. Curfs, Monique Keuter, Jacques F. G. M. Meis, Jos W. M. van der Meer, Recombinant Murine Granulocyte Colony-Stimulating Factor Protects against Acute Disseminated Candida albicans Infection in Nonneutropenic Mice, The Journal of Infectious Diseases, Volume 177, Issue 1, January 1998, Pages 175–181, https://doi.org/10.1086/513812
- Share Icon Share
Abstract
The effect of recombinant granulocyte colony-stimulating factor (rG-CSF) on acute disseminated Candida albicans infection in nonneutropenic mice was investigated. Mice treated with a single dose of rG-CSF showed a significantly reduced mortality (28% vs. 90%; P < .001). The outgrowth of C. albicans from the kidneys, spleens, and livers of rG-CSF-treated mice was significantly reduced (log cfu/g of kidney, 5.54 vs. 7.13; P < .001), as were circulating tumor necrosis factor-a and interleukin-1β. After rG-CSF, the kidneys showed fewer infectious infiltrates, enhanced granulocyte influx, and almost complete absence of hyphal outgrowth. During peritoneal C. albicans infection, rG-CSF enhanced influx of granulocytes to the site of infection, and exudate granulocytes showed increased oxygen radical production. These results indicate that rG-CSF enhances host resistance to disseminated candidiasis in nonneutropenic mice through activation of granulocytes and their recruitment to the site of infection.
- disseminated candidiasis
- granulocyte colony-stimulating factor
- candida albicans
- exudates
- recombinant granulocyte colony stimulating factor
- granulocytes
- interleukins
- reactive oxygen species
- infections
- kidney
- liver
- mice
- mortality
- peritoneum
- spleen
- tumor necrosis
- infiltrates
- single-dose regimen
- host (organism)