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T. L. Yashina, M. O. Favorov, Y. E. Khudyakov, H. A. Fields, O. O. Znoiko, T. V. Shkurko, T. Bonafonte, J. S. Sevall, M. S. Agopian, J. B. Peter, Detection of Hepatitis G Virus (HGV) RNA: Clinical Characteristics of Acute HGV Infection, The Journal of Infectious Diseases, Volume 175, Issue 6, June 1997, Pages 1302–1307, https://doi.org/10.1086/516460
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Abstract
The role of hepatitis G virus (HGV) infection in acute non-A–E hepatitis was investigated in adults with viral hepatitis. HGV RNA was present in 1 of 28 patients with non-A–E hepatitis but 9 of 22 with hepatitis C (P < .003). HGV RNA-positive patients (HGV-infected and HGV-hepatitis C virus [HCV]-coinfected) developed light-to-moderate jaundice. Clinical and biochemical features of HGV-positive and HCV-positive patients and patients with non-A, non-G hepatitis were similar. Three patients with HGV-HCV coinfection, tested within 18 months after disease onset, have remained HGV RNA-positive but have become HCV RNA-negative. Only 1 non-A–E hepatitis patient was confirmed as being infected with HGV alone, suggesting that HGV is not the main etiologic agent of non-A–E hepatitis. Although HGV RNA was significantly associated with hepatitis C, patients with mixed HCV-HGV infections did not demonstrate a more severe course of disease than did patients with HCV infection.