-
Views
-
Cite
Cite
Elisabeth M. H. A. de Kleijn, Joost P. H. Drenth, Gerard J. Pesman, Hans van Druten, Pierre N. M. Demacker, Jos W. M. van der Meer, Circulating and Ex Vivo Production of Pyrogenic Cytokines and Interleukin-1 Receptor Antagonist in 123 Patients with Fever of Unknown Origin, The Journal of Infectious Diseases, Volume 175, Issue 1, January 1997, Pages 191–194, https://doi.org/10.1093/infdis/175.1.191
- Share Icon Share
Abstract
Circulating and ex vivo production of interleukin (IL)-1β, tumor necrosis factor (TNF)-α, IL-6, and IL-1 receptor antagonist (ra) and the diagnostic utility of these cytokines were studied in 123 patients with fever of unknown origin (FUO). Diagnoses were infections, 28; neoplasms, 14; noninfectious inflammatory diseases (NIID), 32; miscellaneous diseases, 10; and none made, 39. IL-1β, IL-6, and IL-1ra concentrations were higher in patients with infections, neoplasms, and NIID than in healthy controls. Patients with infections had higher concentrations of TNF-α than controls. The ex vivo production of IL-1β and IL-1ra in all patients with FUQ did not differ from that in controls; however, production of TNF-α was lower in patients with neoplasms and NIID, and IL6 production was lower in patients with neoplasms. Thirty-five patients with fever did not have elevated cytokines. Although some significant differences were found among the diagnostic subgroups, there was wide variation. Thus, measurement of these cytokines does not aid in the diagnosis of FUO.