-
Views
-
Cite
Cite
Serafino Mansueto, Fortunato P. D'Ancona, Piero Colletti, Raimondo Graceffa, Francesco La Seta, Vincenzo Pecoraro, Giuseppe Gambino, Giuseppina Grillo, Giustina Vitale, Piera Richiusa, Pietro D'Agostino, Enrico Cillari, Alteration of Interleukin-2 (IL-2) and Soluble IL-2 Receptor Secretion in the Sera and Urine of Patients with Rickettsial Boutonneuse Fever, The Journal of Infectious Diseases, Volume 175, Issue 1, January 1997, Pages 142–145, https://doi.org/10.1093/infdis/175.1.142
- Share Icon Share
Abstract
Sera and urine samples from 115 Sicilian patients with boutonneuse fever (BF), obtained at the time of diagnosis and after clinical recovery, were analyzed for concentrations of interleukin (IL)-2 and soluble IL-2 receptor (sIL-2R). There were significantly high levels of sIL-2R in the urine and sera of patients with acute BF compared with healthy controls, and the values returned to normal following successful chemotherapy. The data indicate that the sIL-2R urine concentrations correlated directly with the sIL-2R sera levels. In contrast, in all tested sera and urine samples, IL-2 levels were normal. Furthermore, a reduction in IL-2 production by peripheral blood mononuclear cells from acute BF patients was also observed. sIL-2R represents an unspecific marker useful to monitor the evolution of BF.