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L. Kestens, J. Vingerhoets, M. Peeters, G. Vanham, C. Vereecken, G. Penne, H. Niphuis, P. van Eerd, G. van der Groen, P. Gigase, J. Heeney, Phenotypic and Functional Parameters of Cellular Immunity in a Chimpanzee with a Naturally Acquired Simian Immunodeficiency Virus Infection, The Journal of Infectious Diseases, Volume 172, Issue 4, October 1995, Pages 957–963, https://doi.org/10.1093/infdis/172.4.957
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Abstract
The cellular immunologic and virologic status of a chimpanzee, naturally infected with a human immunodeficiency virus type 1 (HIV-1)-like lentivirus (SIVcpz-ant), was compared longitudinally with those of 3 HIV-1-infected and 5 uninfected chimpanzees for a period of 49 months. Evidence of immune deficiency was not observed in the HIV-1-infected chimpanzees, nor could virus be isolated from plasma. Virus could be isolated from plasma of the SIVcpz-ant-infected chimpanzee, but clinical signs of immune deficiency were never observed. AbsoluteCD4+ cell counts remained relatively stable, but NK cells fluctuated significantly over time and tended to correlate inversely with the virus titer in peripheral blood. Although only CD8+ T cells were directly demonstrated to exert a suppressive effect on viral replication in vitro, the observed fluctuation of NK cells suggests that these cells may also be involved in the interaction with lentivirus infection in this species.