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Keith G. Mansfield, Doug Pauley, Heather L. Young, Andrew A. Lackner, Mycobacterium avium Complex in Macaques with AIDS Is Associated with a Specific Strain of Simian Immunodeficiency Virus and Prolonged Survival after Primary Infection, The Journal of Infectious Diseases, Volume 172, Issue 4, October 1995, Pages 1149–1152, https://doi.org/10.1093/infdis/172.4.1149
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Abstract
Mycobacterium avium complex (MAC) in simian immunodeficiency virus (SIV)-infected macaques is a frequent opportunistic infection that shares many features with the condition in human AIDS patients. A retrospective analysis of necropsies on 135 macaques with SIV-induced simian AIDS that received neither antiretroviral nor antimicrobial therapy revealed that 17% (23/135) were infected with MAC. MAC developed in 31.3% (21/67) of the animals inoculated with uncloned SIVmac251 versus 1.9% (1/53) and 6.7% (1/15) of the animals inoculated with the molecular clones SIVmac239 and SIVmac239/316EM, respectively (P = .001). This is the first example in which the risk of infection with a specific opportunistic organism was affected by the infecting strain of immunodeficiency virus. In addition, animals with MAC had a longer mean survival after primary infection and lower CD4 cell counts at death than animals that did not develop this opportunistic infection. The SIV-inoculated macaque is a valuable model in which to study the pathogenesis of MAC in the immunocompromised host.
- acquired immunodeficiency syndrome
- autopsy
- cd4 count determination procedure
- clone cells
- immunocompromised host
- immunologic deficiency syndromes
- macaca
- mycobacterium avium complex
- opportunistic infections
- simian acquired immunodeficiency syndrome
- simian immunodeficiency virus
- infections
- viruses
- antimicrobials
- anti-retroviral agents
- infection risk