-
Views
-
Cite
Cite
Phillip K. Peterson, Shuxian Hu, Wen S. Sheng, Frederic H. Kravitz, Thomas W. Molitor, Delphi Chatterjee, Chun C. Chao, Thalidomide Inhibits Tumor Necrosis Factor-α Production by Lipopolysaccharide- and Lipoarabinomannan-Stimulated Human Microglial Cells, The Journal of Infectious Diseases, Volume 172, Issue 4, October 1995, Pages 1137–1140, https://doi.org/10.1093/infdis/172.4.1137
- Share Icon Share
Abstract
Tumor necrosis factor-α (TNF-α) is a pathogenic factor in bacterial meningitis. The effect of thalidomide on TNF-α production by microglia, the resident macrophages of the brain, was evaluated. In primary human fetal microglial cell cultures stimulated with lipopolysaccharide or lipoarabinomannan, thalidomide inhibited TNF-α release in a dose-dependent manner. The inhibitory effect of thalidomide was similar to that of dexamethasone, although expression of TNF-α mRNA in microglial cells was reduced only by thalidomide. The results of this in vitro study suggest that thalidomide could have therapeutic potential in gram-negative bacterial and tuberculous meningitis.