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Rhoda L. Ashley, Lawrence Corey, Julie Dalessio, Patricia Wilson, Mike Remington, Gail Barnum, Peter Trethewey, Protein-Specific Cervical Antibody Responses to Primary Genital Herpes Simplex Virus Type 2 Infections, The Journal of Infectious Diseases, Volume 170, Issue 1, July 1994, Pages 20–26, https://doi.org/10.1093/infdis/170.1.20
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Abstract
Antibodies to herpes simplex virus (HSV) have been demonstrated in cervicovaginal secretions but have not been analyzed for their viral protein targets, prevalence, isotype, or kinetics of development. A method was devised to collect cervical secretions from women with primary genital HSV-2. By Western blot, cervical IgG and IgA responses to HSV-2 proteins VP5, gB, and gD were detected in most patients within 2 weeks of onset and to gC/gE within 3 weeks. Cervical IgA and IgG responses to gG, VPI6, and ICP35 developed later and were more variable. Cervical IgM to most proteins appeared within 6–10 days. Cervical IgA and IgG persisted for weeks, but cervical IgM waned. Western blot profiles of serum IgG and cervical IgG to individual HSV-2 proteins were similar; those of serum IgA and cervical IgA differed. These findings suggest a universal, complex immune response to HSV-2 infection in the female genital tract.
- simplexvirus
- western blotting
- immune response
- genital herpes
- gonococcal infection
- antibody formation
- bodily secretions
- cervix mucus
- gas chromatography
- gabon
- gadolinium
- female genitalia
- georgia (republic)
- great britain
- grenada
- human herpesvirus 2
- immunoglobulin isotypes
- neisseria gonorrhoeae
- viral proteins
- immunoglobulin a
- immunoglobulin g
- immunoglobulin m
- infections
- antibodies
- kinetics
- viruses
- genital system
- united kingdom
- symptom onset
- herpes simplex type 2 infection