-
Views
-
Cite
Cite
Judy F. Lew, Jose Valdesuso, Timo Vesikari, Albert Z. Kapikian, Xi Jiang, Mary K. Estes, Kim Y. Green, Detection of Norwalk Virus or Norwalk-like Virus Infections in Finnish Infants and Young Children, The Journal of Infectious Diseases, Volume 169, Issue 6, June 1994, Pages 1364–1367, https://doi.org/10.1093/infdis/169.6.1364
- Share Icon Share
Abstract
Norwalk virus (NV) and Norwalk-like viruses are important causes of epidemic nonbacterial gastroenteritis in older children and adults. Serologic responses to NV of 154 Finnish infants and young children participating in a rotavirus vaccine study were examined by ELISA with a recently available baculovirus-expressed recombinant NV capsid protein. In 4 serially collected sera (at the median ages of 3, 4, 14, and 23 months), 49% of children had at least one NV infection over the ∼2-year study period. Children with low NV-specificIgG titers (<1:50) at the median age of 4 or 14 months were significantly more likely to acquire an NV infection by the median age of 14 or 23 months, respectively, than children who had higher NV IgG titers (> 1:50) (P < .05). Thus, NV or Norwalk-like virus infections are more common in infants and young children than previously believed, and antibody to NV may be protective against such infections.