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Phyllis Flomenberg, Jill Babbitt, William R. Drobyski, Robert C. Ash, Donald R. Carrigan, Gerald V. Sedmak, Timothy McAuliffe, Bruce Camitta, Mary M. Horowitz, Nancy Bunin, James T. Casper, Increasing Incidence of Adenovirus Disease in Bone Marrow Transplant Recipients, The Journal of Infectious Diseases, Volume 169, Issue 4, April 1994, Pages 775–781, https://doi.org/10.1093/infdis/169.4.775
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Abstract
Adenovirus infections in 201 bone marrow transplant (BMT) recipients over 4 years were retrospectively reviewed. Forty-two patients (20.9%) had positive adenovirus cultures after BMT. There was a higher incidence of adenovirus infections in pediatric patients than in adults (31.3% vs. 13.6%, P = .003). In addition, the time of onset of adenovirus infection after transplant was earlier in pediatric patients (mean, <30 days) than in adults (<90 days). Adenovirus type 35 was the most common serotype identified. One-third of adenovirus-positive patients had definite or probable adenovirus disease. Moderate to severe acute graft-versus-host disease and isolation of adenovirus from two or more sites were significant risk factors for adenovirus disease. This report documents a higher incidence of both adenovirus infection and disease than do previous studies. Adenovirus may emerge as a more frequent pathogen as more high-risk BMT transplants are done.