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Peter F. Barnes, Cara L. Grisso, John S. Abrams, Hamid Band, Thomas H. Rea, Robert L. Modlin, γδ T Lymphocytes in Human Tuberculosis, The Journal of Infectious Diseases, Volume 165, Issue 3, March 1992, Pages 506–512, https://doi.org/10.1093/infdis/165.3.506
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Abstract
The manifestations of tuberculous infection reflect the immune response to infection. Most healthy tuberculin reactors develop protective immunity; tuberculous pleuritis reflects a resistant response manifest by mild disease, whereas advanced pulmonary and miliary tuberculosis reflect ineffective immunity. The role of γδ T cells was assessed in tuberculous infection by evaluating expansion of these cells from blood mononuclear cells after stimulation with Mycobacterium tuberculosis. After culture in vitro, the percentages of γδ+ cells were significantly greater in patients with protective and resistant immunity (tuberculin reactors, 25% ± 4%; tuberculous pleuritis, 30% ± 7%) than in those with ineffective immunity (advanced pulmonary tuberculosis, 9% ± 3%; miliary tuberculosis, 2% ± 1%). In leprosy, expansion of γδ+ cells was greater in immunologically resistant tuberculoid patients (32% ± 4%) than in Mycobacterium leprae-unresponsive lepromatous patients (9% ± 2%). M. tuberculosis-reactive γδ T cell lines produced interferon-γ, granulocyte-macrophage colony-stimulating factor, interleukin-3, and tumor necrosis factor-α, cytokines that activate macrophages and may contribute to mycobacterial elimination. These findings suggest that γδ T cells contribute to immune resistance against M. tuberculosis.
- cytokine
- excretory function
- lung
- immune response
- pulmonary tuberculosis
- granulocyte-macrophage colony-stimulating factor
- immunity
- interferons
- interleukin-3
- leprosy
- macrophages
- mycobacterium leprae
- mycobacterium tuberculosis
- t-lymphocytes
- tuberculin
- tuberculosis
- miliary tuberculosis
- pleural tuberculosis
- infections
- human leukocyte interferon
- tumor necrosis
- mononuclear cells