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A. Stapleton, S. Moseley, W. E. Stamm, Urovirulence Determinants in Escherichia coli Isolates Causing First-Episode and Recurrent Cystitis in Women, The Journal of Infectious Diseases, Volume 163, Issue 4, April 1991, Pages 773–779, https://doi.org/10.1093/infdis/163.4.773
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Abstract
To assess the prevalence of urovirulence determinants among Escherichia coli isolates from women with acute uncomplicated cystitis,121isolatesfrom 87 womenwith first-episodeor recurrent cystitis and 156 fecal isolates from 52 women without recent urinary tract infection were tested using DNA probes for P fimbriae, hemolysin, aerobactin, and diffuse adhesin and for expression of hemolysin and P and F adhesins. P fimbrial genotype (P = .002), hemolysin phenotype (P = .007), and the diffuse adhesin determinant (P = .03), but not aerobactin, were found more frequently in E. coli from women with acute cystitis, and expression of the F adhesin (41%) was more common than the P adhesin (24%; P = .001). E. coli isolates that caused cystitis in women using diaphragms had fewer virulence determinants than those from nonusers (P = .04), suggesting that diaphragm use may allow infection with less virulent E. coli.