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David L. Pacini, Albert M. Collier, Frederick W. Henderson, Adenovirus Infections and Respiratory Illnesses in Children in Group Day Care, The Journal of Infectious Diseases, Volume 156, Issue 6, December 1987, Pages 920–927, https://doi.org/10.1093/infdis/156.6.920
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Abstract
Adenovirus infections and respiratory illnesses among 123 children attending a research day care center were analyzed from data collected prospectively from 1967 through 1981. During the 15-year study period, 298 adenovirus isolates were recovered from respiratory secretions of the study children, and five different serotypes were identified, with types 1, 2, and 5 accounting for 92% of the typed isolates. Annual incidence of each serotype varied greatly, with types 2 and 5 predominating before 1975 and type 1 thereafter. Exposure to adenovirus in the day care center correlated with acquisition of infection. Through two years of age, children were exposed to 3.4 ± 0.9 (mean ± SD) different serotypes and became infected by 2.1 ± 0.8 different types. Most infections occurred before the child's second birthday, and incidence was highest from six to 12 months of age (1.4 primary infections/child-year). Mild and febrile illness accompanied 75% of primary isolations. Otitis media occurred in 37% of illnesses over all ages and in >50% of illnesses among infants.
