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David I. Bernstein, Lawrence R. Stanberry, Christopher J. Harrison, Rakesh Shukla, John C. Kappes, Martin G. Myers, Antibody Response to Herpes Simplex Virus Glycoprotein D: Effects of Acyclovir and Relation to Recurrence, The Journal of Infectious Diseases, Volume 156, Issue 3, September 1987, Pages 423–429, https://doi.org/10.1093/infdis/156.3.423
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Abstract
We developed an enzyme-linked immunosorbent assay (ELISA) for measuring the antibody response to herpes simplex virus (HSV) glycoprotein D (gD). The ELISA was specific and more sensitive than immunoblotting techniques. Antibody to HSV gD was detected in 10of 12sera (geometric mean titer, 36.3) obtained from HSV-2-infected guinea pigs 14 days after intravaginal inoculation, and the titer increased to ⩾5,120 on day 60. Therapy with acyclovir delayed and diminished the antibody response to gD, although by day 60 the titers of antibody to gD in acyclovir-treated animals were not significantly different from those in controls. An increased titer of antibody to gD seemed to be associated with a reduced number of recurrent episodes and to a reduced number of days with recurrent lesions.