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Elaine Tuomanen, Bruno Hengstler, Roland Rich, Michael A. Bray, Oto Zak, Alexander Tomasz, Nonsteroidal Anti-Inflammatory Agents in the Therapy for Experimental Pneumococcal Meningitis, The Journal of Infectious Diseases, Volume 155, Issue 5, May 1987, Pages 985–990, https://doi.org/10.1093/infdis/155.5.985
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Abstract
An increased inflammatory mass in the subarachnoid space during bacterial meningitis may correlate with a poor outcome of disease. Using a rabbit model of pneumococcal meningitis, we sought to reduce this inflammatory process. The ability of the pneumococcal cell wall to cause death and to generate leukocytosis and abnormal chemistry in cerebrospinal fluid was prevented when animals were treated with inhibitors of the cyclooxygenase pathway of arachidonate metabolism. Bacterial lysis by ampicillin led to release of cell wall that caused a significant, transient increase in meningeal inflammation. This inflammatory burst was also prevented by administering cyclooxygenase inhib-itors concurrently with the antibiotic.