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Louis P. Gangarosa, James M. Hill, Barry L. Thompson, Carol Leggett, J. Peter Kissing, Iontophoresis of Vidarabine Monophosphate for Herpes Orolabialis, The Journal of Infectious Diseases, Volume 154, Issue 6, December 1986, Pages 930–934, https://doi.org/10.1093/infdis/154.6.930
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Abstract
The cutaneous application of antiviral agents was studied by iontophoresis, a process that increases penetration of most drugs 20- to 60-fold. Twenty-seven subjects with vesicular orolabial herpes were treated one time in a double-blind, placebo-controlled clinical study: nine received vidarabine monophosphate (ara-AMP), nine received acyclovir (ACV), and nine received NaCl. Ara-AMP-treated lesions yielded lower titers of virus after 24 hr compared with lesions treated with NaCI or ACV (P < .05). Ara-AMP significantly decreased the duration of shedding of virus (P < .05) and time to dry crust (P < .05) compared with the other two agents. There was a trend toward decreased healing time after araAMP treatment.