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Frank R. Venezio, Cathy DiVincenzo, Randall Sherman, Mark Reichman, Thomas C. Origitano, Kenneth Thompson, O. H. Reichman, Bactericidal Effects of Photoradiation Therapy With Hematoporphyrin Derivative, The Journal of Infectious Diseases, Volume 151, Issue 1, January 1985, Pages 166–169, https://doi.org/10.1093/infdis/151.1.166
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Abstract
Hematoporphyrin derivative (Hpd) localizes selectively in malignant and rapidly metabolizing tissues and undergoes a cytotoxic reaction when exposed to light of a specific wavelength. Hpd has been studied extensively with regard to the diagnosis and treatment of tumors but not with regard to bactericidal activity. This investigation assessed the effect of light-activated Hpd on various microorganisms, on human polymorphonuclear leukocytes, and on the interactions of polymorphonuclear leukocytes and bacteria. Light-activated Hpd was 99.9% bactericidal against Staphylococcus aureus, Streptococcus faecalis, Bacteroides fragilis, Streptococcus M-G intermedius, Streptococcus mutans, Peptostreptococcus anaerobius, Peptococcus magnus, and Clostridium perfringens, but did not affect Escherichia coli, Pseudomonas aeruginosa, or Candida albicans. Photoactivation of Hpd rendered 98% of polymorphonuclear leukocytes inviable. Combinations of light-activated Hpd and polymorphonuclear leukocytes had a 4-log (99.99%) bactericidal effect on both intra- and extracellular S. aureus. The ability of Hpd to localize in inflammatory tissues may have therapeutic applications in the treatment of abscesses.
- pseudomonas aeruginosa
- staphylococcus aureus
- abscess
- bacteroides fragilis
- candida albicans
- clostridium
- enterococcus faecalis
- hematoporphyrin derivative
- neutrophils
- peptococcus
- peptostreptococcus
- photochemotherapy
- phototherapy
- streptococcus
- streptococcus mutans
- bacteria
- diagnosis
- neoplasms
- hypersensitivity, antibody-mediated
- escherichia coli
- microorganisms