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R. G. Faix, S. E. Zweig, J. F. Kummer, D. Moore, D. J. Lang, Cytomegalovirus-Specific Cell-Mediated Immunity During Pregnancy in Lower Socioeconomic Class Adolescents, The Journal of Infectious Diseases, Volume 148, Issue 4, October 1983, Pages 621–629, https://doi.org/10.1093/infdis/148.4.621
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Abstract
The role of maternal cytomegalovirus (CMV)-specific cellular immunity in gestational CMV excretion and transmission of congenital infection was assessed by studying CMV-specific mononuclear proliferation (CMV-MP) longitudinally during pregnancy in 59 lower socioeconomic class adolescents. CMV-MP was absent in mothers seropositive for CMV Oil more than 40% of occasions tested, but no significant difference was noted at any time in frequency or degree of CMP-MP between the 16 mothers who shed virus and the 29 who were seropositive for CMV but did not shed virus. The presence of CMV-MP did not preclude gestational CMV excretion. The lone mother who bore a congenitally infected infant lacked CMV-MP on all three occasions when she shed virus. CMV-MP was noted in cord blood from 14 uninfected infants of seropositive mothers. Maternal CMV-specific cellular immunity is not the major determinant of gestational CMV excretion, but the extent of its role in modulating transmission of congenital infection is yet unclear.